Systems and methods for digitally equalizing a signal in a distributed antenna system are provided. In one embodiment, a signal processing device within a distributed antenna system comprises a signal path within a signal processing board, the signal path having an uncompensated distortion function of G(ω) with a system response represented by y(n); and a compensator coupled to the signal path, the compensator having a finite impulse response (FIR) filter with an impulse response function represented by H(ω), the compensator having an FIR filter parameter vector {right arrow over (h)} determined from an estimated system response y(n) of the signal path to an input comb signal x(n), wherein y(n) is estimated from interpolated measured output responses of the signal path to a plurality of frequency sweep signal test inputs.