Invention Grant
US08440402B2 Gene detection assay for improving the likelihood of an effective response to a HER2 antibody cancer therapy
有权
用于改善对HER2抗体癌症治疗有效应答的可能性的基因检测测定
- Patent Title: Gene detection assay for improving the likelihood of an effective response to a HER2 antibody cancer therapy
- Patent Title (中): 用于改善对HER2抗体癌症治疗有效应答的可能性的基因检测测定
-
Application No.: US13323322Application Date: 2011-12-12
-
Publication No.: US08440402B2Publication Date: 2013-05-14
- Inventor: Robert D. Mass
- Applicant: Robert D. Mass
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Arnold & Porter LLP
- Agent Diane Marschang; Ginger R. Dreger
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/574
Abstract:
The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing HER2, as determined by a gene amplification assay, with a HER2 antibody. Such method comprises administering a cancer-treating dose of the HER2 antibody, preferably in addition to chemotherapeutic agents, to a subject in whose tumor cells her2 has been found to be amplified e.g., by fluorescent in situ hybridization.
Public/Granted literature
Information query
