Invention Grant
US08440445B2 Neutral protease (NP) and product by using neutral protease for tissue dissociation as well as method for the production thereof
有权
中性蛋白酶（NP）和产品通过使用中性蛋白酶进行组织解离以及其制备方法
- Patent Title: Neutral protease (NP) and product by using neutral protease for tissue dissociation as well as method for the production thereof
- Patent Title (中): 中性蛋白酶（NP）和产品通过使用中性蛋白酶进行组织解离以及其制备方法
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Application No.: US10869313Application Date: 2004-06-16
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Publication No.: US08440445B2Publication Date: 2013-05-14
- Inventor: Manfred Kurfürst , Christian Raemsch , Nicole Raemsch-Guenther , Olaf Friedrich , Silke Huettler , Daniel Brandhorst , Thierry Berney , Pascal Bucher , Heide Brandhorst
- Applicant: Manfred Kurfürst , Christian Raemsch , Nicole Raemsch-Guenther , Olaf Friedrich , Silke Huettler , Daniel Brandhorst , Thierry Berney , Pascal Bucher , Heide Brandhorst
- Applicant Address: DE Uetersen
- Assignee: Nordmark Arzneimittel GmbH & Co. KG
- Current Assignee: Nordmark Arzneimittel GmbH & Co. KG
- Current Assignee Address: DE Uetersen
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: DE10331171 20030709
- Main IPC: C12N9/52
- IPC: C12N9/52
Abstract:
The use of a neutral protease (NP) together with a collagenase consists in that a neutral protease which is not contained in a collagenase enzyme preparation and which is not produced by a recombinant production ia mixed before the beginning of a tissue dissociation with a collagenase or a collagenase enzyme preparation with an individual dosage of the quantitative proportions of neutral protease and collagenase for improving the isolation results with respect to yield, viability and integrity of the cells.
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