Invention Grant
- Patent Title: Oligonucleotide conjugates
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Application No.: US12504931Application Date: 2009-07-17
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Publication No.: US08440635B2Publication Date: 2013-05-14
- Inventor: Sergei M. Gryaznov , Krisztina Pongracz , Richard L. Tolman , Gregg B. Morin
- Applicant: Sergei M. Gryaznov , Krisztina Pongracz , Richard L. Tolman , Gregg B. Morin
- Applicant Address: US CA Menlo Park
- Assignee: Geron Corporation
- Current Assignee: Geron Corporation
- Current Assignee Address: US CA Menlo Park
- Agent Leslie A. Mooi
- Main IPC: A01N43/04
- IPC: A01N43/04 ; C07H21/02 ; C07H21/04 ; C12Q1/68 ; C12N5/00
Abstract:
Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
Public/Granted literature
- US20100016416A1 Oligonucleotide Conjugates Public/Granted day:2010-01-21
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