Invention Grant
- Patent Title: Treatment of sleep-wake disorders
- Patent Title (中): 治疗睡眠障碍
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Application No.: US11921995Application Date: 2006-06-07
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Publication No.: US08440715B2Publication Date: 2013-05-14
- Inventor: Abdallah Ahnaou , Wilhelmus H. L. M. Drinkenburg , Joseph Palumbo , Jonathan Sporn
- Applicant: Abdallah Ahnaou , Wilhelmus H. L. M. Drinkenburg , Joseph Palumbo , Jonathan Sporn
- Applicant Address: KR Seoul
- Assignee: SK Biopharmaceuticals Co., Ltd.
- Current Assignee: SK Biopharmaceuticals Co., Ltd.
- Current Assignee Address: KR Seoul
- Agency: Myers Bigel Sibley & Sajovec, P.A.
- International Application: PCT/US2006/022407 WO 20060607
- International Announcement: WO2006/133393 WO 20061214
- Main IPC: A01N47/10
- IPC: A01N47/10 ; A01N33/02 ; A01N33/18 ; A01N33/24 ; A61K31/27 ; A61K31/135 ; A61K31/04

Abstract:
This invention is directed to a method of treating Excessive daytime Sleepiness (EDS) in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the ox en atom.
Public/Granted literature
- US20090312416A1 TREATMENT OF SLEEP-WAKE DISORDERS Public/Granted day:2009-12-17
Information query
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