Invention Grant
- Patent Title: N-terminal VDAC variants and uses thereof
- Patent Title (中): N端VDAC变体及其用途
-
Application No.: US12296239Application Date: 2007-04-10
-
Publication No.: US08440788B2Publication Date: 2013-05-14
- Inventor: Varda Shoshan-Barmatz , Doron Calo
- Applicant: Varda Shoshan-Barmatz , Doron Calo
- Applicant Address: IL Beer Sheva
- Assignee: Ben-Gurion University of The Negev Research and Development Authority Ltd.
- Current Assignee: Ben-Gurion University of The Negev Research and Development Authority Ltd.
- Current Assignee Address: IL Beer Sheva
- Agency: Booth Udall Fuller, PLC
- Agent Rodney J. Fuller
- International Application: PCT/IL2007/000455 WO 20070410
- International Announcement: WO2007/113837 WO 20071011
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K38/00 ; A61K48/00 ; A61P43/00 ; C07H21/04 ; C12N15/63 ; C12N15/85
Abstract:
The present invention relates generally to variants and peptides of the mitochondrial protein, voltage-dependent anion channel (VDAC) and to polynucleotides encoding same. In particular, the present invention is directed to N-terminal truncated and mutated VDAC and specific amino acid and polynucleotide sequences thereof useful in inhibiting apoptosis, and to pharmaceutical compositions comprising same useful in the treatment of diseases associated with excess apoptosis.
Public/Granted literature
- US20100075898A1 N-TERMINAL VDAC VARIANTS AND USES THEREOF Public/Granted day:2010-03-25
Information query
