Invention Grant
- Patent Title: Therapeutic substituted beta-lactams
- Patent Title (中): 治疗性取代的β-内酰胺
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Application No.: US12372417Application Date: 2009-02-17
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Publication No.: US08440819B2Publication Date: 2013-05-14
- Inventor: David W. Old
- Applicant: David W. Old
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Kevin J. Forrestal
- Main IPC: C07D205/08
- IPC: C07D205/08 ; A61K31/397 ; A61P17/14 ; A61P27/06

Abstract:
A compound having a structure or a pharmaceutically acceptable salt thereof, or a prodrug thereof; wherein a dashed line represents the presence or absence of a bond; Y has from 0 to 14 carbon atoms and is: an organic acid functional group, or an amide or ester thereof; hydroxymethyl or an ether thereof; or a tetrazolyl functional group; A is —(CH2)6—, cis-CH2CH═CH—(CH2)3—, or —CH2C≡C—(CH2)3—, wherein 1 or 2 carbon atoms may be replaced by S or O; or A is —(CH2)m—Ar—(CH2)o— wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 -CH2— may be replaced by S or O, and 1 -CH2—CH2— may be replaced by —CH═CH— or —C≡C—; J is hydrogen, OH, O, SH, S, C1-6 alkyl, —O—(C1-6 alkyl), —S—(C1-6 alkyl), F, Cl, Br, I, CN, or CF3; and B is aryl or heteroaryl, is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
Public/Granted literature
- US20090215740A1 THERAPEUTIC SUBSTITUTED BETA-LACTAMS Public/Granted day:2009-08-27
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