A device and a method for driving a light-emitting diode include using multiple current guiding control circuits to drive multiple LED modules. Each of the current guiding control circuits includes at least two transistors connected in parallel to constitute at least two switch circuits. Each of the current guiding control circuits permits or prevents electric current to flow to an immediate downstream one of the LED modules in response to a predetermined voltage level of the positive part of a voltage source. The respective the current guiding control circuits are responsive to different voltage levels. As a result, a maximum number of LED modules are driven to emit light at a given voltage level, thereby achieving the purposes of efficiently utilizing electric power and reducing power loss.