A personal security backpack and method of use include a portable container having a first compartment and a second compartment, the second compartment having an audible alarm siren window for transmission of an audible siren; a strap attached to the portable container; and an alarm system responsive to at least one activation signal, the alarm system includes an alarm system circuit removably disposed in the second compartment; an audible alarm siren operably connected to the alarm system circuit and responsive to the activation signal to generate the audible siren; and a microphone operably connected to the alarm system circuit, the microphone being responsive to the activation signal, responsive to a user voice, and selectively unresponsive to the audible siren to generate a voice signal.