An image sensing systems supports independently setting sensor parameters in two or more different regions of interest. In one implementation resolution, exposure time, and gain are independently selectable in each region of interest. Independently setting exposure time and gain in different regions of interest improves image recognition when there are large differences in the illumination of objects within an image. Independently setting resolution permits the resolution to be selectively increased in regions of interest requiring high resolution in order to reduce the pixel data bandwidth and processing requirements.