According to one embodiment, a data detection system includes a coefficient-and-variance engine for selecting which infinite impulse response (IIR) filter and prediction error variance to process and store at any time, and a maximum-likelihood sequence detector. The coefficient-and-variance engine comprises a filter bank storing a plurality of IIR filters that represent a plurality of data-dependent noise whitening or noise prediction filters; a least-mean square (LMS) engine for adapting each IIR filter to actual noise conditions: a variance hank storing a plurality of prediction error variance values; and a data-dependent prediction error variance computation unit which updates the plurality of prediction error variance values. The maximum-likelihood sequence detector includes a metric computation unit that employs the plurality of IIR filters in the filter bank and the plurality of prediction error variances in the variance bank to adaptively compute detector branch metrics. Other systems and methods are also described in other embodiments.