Devices and methods of the present invention are directed to positioning a patient in a prone position that exposes the posterior thoracic lumbar spine during a surgical procedure, such as a laminectomy procedure. The device has at least three support members, with a first support member configured and adapted to support at least a portion of a patient's torso and the patient's hips; a second support member, generally contiguous with the first, configured and adapted to contact a patient's thighs and to position the patient's thighs in a desired angular position relative to the patient's hips and torso; and a third support member, generally contiguous with the second support member, adapted to support a patient's knees and lower legs and to position the patient's lower legs in a desired angular position relative to the patient's torso and thighs. A patient is positioned in the frame device prior to being anesthetized while the patient is lying supine and, during or following administration of anesthesia, the patient (mounted in the device) is rolled onto an operating table and positioned in a prone position. Operation on the posterior thorical-lumbar spine in this position is especially advantageous, and the spinal canal remains virtually bloodless, providing excellent visualization during the surgical procedure. When the surgery is finished, the process is reversed.