The present invention realizes a pneumatic tire for a motorcycle, in which durability in running straight at a relatively high speed and tread surface gripping properties during high-speed cornering are made compatible and, in particular, a pneumatic tire for a motorcycle, which tire is capable of demonstrating appropriate durability and driving stability in accordance with inputs even if these inputs differ between running straight, cornering left and cornering right. The tread portion 3 is constituted of plural types of rubbers 11-13 adjacent to each other in the tire widthwise direction and sectioned into at least a center region A at the center portion of the tire including the tire equatorial plane and two side regions B1, B2 at respective sides of the tire. 300% modulus of rubber 11 constituting the center region is higher than 300% modulus of each of rubbers 12, 13 constituting the side regions, and 300% moduli of the rubbers constituting the side regions differ between one side region and the other side region.