A lens barrier device and an image pickup apparatus, comprising a moving barrel, a fixed barrel, a base plate, two vanes and a rotating plate. The base plate has a central window. Two vanes are inserted into the base plate and have a pivot and a control protrusion respectively. The rotating plate has a hollow part and two first grooves. A linking-up body is axially extended from the rotating plate, and has a first guiding protrusion. The moving barrel has a second guiding convex dot. The fixed barrel has a second groove and a third groove. The first guiding protrusion, the second guiding protrusion and the control convex dot are inserted into the first groove, the second groove and the third groove respectively. After the first guiding protrusion is driven, the rotating plate is linked to rotate to open or close the two vanes.