Invention Grant
US08445017B2 Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
有权
用于基因递送的可生物降解的交联阳离子多嵌段共聚物及其制备方法
- Patent Title: Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
- Patent Title (中): 用于基因递送的可生物降解的交联阳离子多嵌段共聚物及其制备方法
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Application No.: US13237168Application Date: 2011-09-20
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Publication No.: US08445017B2Publication Date: 2013-05-21
- Inventor: Gregory Slobodkin , Majed Matar , Jason Fewell , Khursheed Anwer
- Applicant: Gregory Slobodkin , Majed Matar , Jason Fewell , Khursheed Anwer
- Applicant Address: US AL Huntsville
- Assignee: Egen, Inc.
- Current Assignee: Egen, Inc.
- Current Assignee Address: US AL Huntsville
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: A61K48/00
- IPC: A61K48/00
Abstract:
A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.
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