Invention Grant
US08445193B2 Microwell array chip for detecting antigen-specific lymphocytes, method of detecting and method of manufacturing antigen-specific lymphocytes, and method of cloning antigen-specific lymphocyte antigen receptor genes
有权
用于检测抗原特异性淋巴细胞的微孔阵列芯片，检测方法和抗原特异性淋巴细胞的制造方法以及克隆抗原特异性淋巴细胞抗原受体基因的方法
- Patent Title: Microwell array chip for detecting antigen-specific lymphocytes, method of detecting and method of manufacturing antigen-specific lymphocytes, and method of cloning antigen-specific lymphocyte antigen receptor genes
- Patent Title (中): 用于检测抗原特异性淋巴细胞的微孔阵列芯片，检测方法和抗原特异性淋巴细胞的制造方法以及克隆抗原特异性淋巴细胞抗原受体基因的方法
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Application No.: US12337481Application Date: 2008-12-17
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Publication No.: US08445193B2Publication Date: 2013-05-21
- Inventor: Atsushi Muraguchi , Hiroyuki Kishi , Eiichi Tamiya , Masayasu Suzuki
- Applicant: Atsushi Muraguchi , Hiroyuki Kishi , Eiichi Tamiya , Masayasu Suzuki
- Applicant Address: FR Roussay
- Assignee: Vivalis
- Current Assignee: Vivalis
- Current Assignee Address: FR Roussay
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2002-331031 20021114; JP2002-346728 20021129
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C12N5/06 ; C12N5/08 ; C12N5/00
Abstract:
A microwell array chip that has multiple microwells and is employed to contain a single lymphocyte specimen in each microwell and detect antigen-specific lymphocytes in single units; wherein the microwell array chip is of a shape and of dimensions where only one lymphocyte is contained in each microwell. A method of detecting antigen-specific lymphocytes comprising the steps of adding antigen to each microwell in the above microwell array chip, stimulating the lymphocyte specimen, and detecting lymphocyte specimens reacting with the antigen.
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