Invention Grant
US08445245B2 Mutant MT-SP1 proteases with altered substrate specificity or activity
有权
具有改变的底物特异性或活性的突变体MT-SP1蛋白酶
- Patent Title: Mutant MT-SP1 proteases with altered substrate specificity or activity
- Patent Title (中): 具有改变的底物特异性或活性的突变体MT-SP1蛋白酶
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Application No.: US13065182Application Date: 2011-03-15
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Publication No.: US08445245B2Publication Date: 2013-05-21
- Inventor: Sandra Waugh Ruggles , Jack Nguyen
- Applicant: Sandra Waugh Ruggles , Jack Nguyen
- Applicant Address: US CA South San Francisco
- Assignee: Catalyst Biosciences, Inc.
- Current Assignee: Catalyst Biosciences, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: McKenna Long & Aldridge LLP
- Agent Stephanie Seidman
- Main IPC: C12N9/00
- IPC: C12N9/00
Abstract:
MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.
Public/Granted literature
- US20110177581A1 Mutant MT-SP1 proteases with altered substrate specificity or activity Public/Granted day:2011-07-21
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