Invention Grant
US08445251B2 Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
有权
合理设计的具有非回文识别序列的单链大范围核酸酶
- Patent Title: Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
- Patent Title (中): 合理设计的具有非回文识别序列的单链大范围核酸酶
-
Application No.: US12771163Application Date: 2010-04-30
-
Publication No.: US08445251B2Publication Date: 2013-05-21
- Inventor: James J. Smith , Derek Jantz
- Applicant: James J. Smith , Derek Jantz
- Applicant Address: US NC Durham
- Assignee: Precision BioSciences, Inc.
- Current Assignee: Precision BioSciences, Inc.
- Current Assignee Address: US NC Durham
- Agency: Wilmer Cutler Pickering Hale and Dorr LLP
- Main IPC: C12N9/16
- IPC: C12N9/16 ; C07K14/00
Abstract:
Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases.
Public/Granted literature
- US20100311817A1 RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES Public/Granted day:2010-12-09
Information query
