Invention Grant
US08445267B2 Tyrosine-modified recombinant rAAV vector compositions and methods for use
有权
酪氨酸修饰的重组rAAV载体组合物和使用的方法
- Patent Title: Tyrosine-modified recombinant rAAV vector compositions and methods for use
- Patent Title (中): 酪氨酸修饰的重组rAAV载体组合物和使用的方法
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Application No.: US12595196Application Date: 2008-04-08
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Publication No.: US08445267B2Publication Date: 2013-05-21
- Inventor: Li Zhong , Sergei Zolotukhin , Lakshmanan Govindasamy , Mavis Agbandje-McKenna , Arun Srivastava
- Applicant: Li Zhong , Sergei Zolotukhin , Lakshmanan Govindasamy , Mavis Agbandje-McKenna , Arun Srivastava
- Applicant Address: US FL Gainesville
- Assignee: University of Florida Research Foundation, Inc.
- Current Assignee: University of Florida Research Foundation, Inc.
- Current Assignee Address: US FL Gainesville
- Agency: Haynes and Boone, LLP
- International Application: PCT/US2008/059647 WO 20080408
- International Announcement: WO2008/124724 WO 20081016
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N15/09
Abstract:
Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors.
Public/Granted literature
- US20100104561A1 TYROSINE-MODIFIED RECOMBINANT rAAV VECTOR COMPOSITIONS AND METHODS FOR USE Public/Granted day:2010-04-29
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