A method of manufacturing a semiconductor device including a plurality of hole patterns is disclosed. The method includes: forming a plurality of first line patterns and a plurality of first space patterns extending in a first direction; forming a plurality of second line patterns and a plurality of second space patterns extending in a second direction, on the plurality of first line patterns and the plurality of first space patterns; forming a plurality of first hole patterns where the plurality of first space patterns and the plurality of second space patterns cross each other; and forming a plurality of second hole patterns where the plurality of first line patterns and the plurality of second line patterns cross each other.