Invention Grant
- Patent Title: Use on minicircle vectors for cardiac gene therapy
- Patent Title (中): 使用小环向量进行心脏基因治疗
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Application No.: US12925483Application Date: 2010-10-22
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Publication No.: US08445454B2Publication Date: 2013-05-21
- Inventor: Joseph Wu , Mark A. Kay , Mei Huang , Zhi-Ying Chen
- Applicant: Joseph Wu , Mark A. Kay , Mei Huang , Zhi-Ying Chen
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04 ; C07H21/02 ; C12N15/63
Abstract:
Compositions and methods are provided for the treatment of an ischemic cardiovascular condition by providing a patient with a novel non-viral minicircle DNA vector comprising polynucleotide sequences that potentiate HIF-1 activity, including RNAi or antisense agents selective for proteins involved in HIF1 inactivation.
Public/Granted literature
- US20110118333A1 Use on Minicircle vectors for cardiac gene therapy Public/Granted day:2011-05-19
Information query
