Invention Grant
US08445473B2 Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof
有权
杂芳基取代的双环Smac模拟物及其用途
- Patent Title: Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof
- Patent Title (中): 杂芳基取代的双环Smac模拟物及其用途
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Application No.: US12937114Application Date: 2009-04-13
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Publication No.: US08445473B2Publication Date: 2013-05-21
- Inventor: Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska
- Applicant: Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Casimir Jones SC
- International Application: PCT/US2009/040312 WO 20090413
- International Announcement: WO2009/126947 WO 20091015
- Main IPC: C07D403/04
- IPC: C07D403/04 ; C07D403/02 ; C07D235/06
Abstract:
The invention relates to heteroaryl-substituted bicyclic mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
Public/Granted literature
- US20110046189A1 HETEROARYL-SUBSTITUTED BICYCLIC SMAC MIMETICS AND THE USES THEREOF Public/Granted day:2011-02-24
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