Invention Grant
- Patent Title: Supramolecular complexes as photoactivated DNA cleavage agents
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Application No.: US12610729Application Date: 2009-11-02
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Publication No.: US08445475B2Publication Date: 2013-05-21
- Inventor: Karen Brewer , Shawn Swavey
- Applicant: Karen Brewer , Shawn Swavey
- Applicant Address: US VA Blacksburg
- Assignee: Virginia Tech Intellectual Properties, Inc.
- Current Assignee: Virginia Tech Intellectual Properties, Inc.
- Current Assignee Address: US VA Blacksburg
- Agency: Whitham Curtis Christofferson & Cook, PC
- Main IPC: A61K31/555
- IPC: A61K31/555 ; A01N55/02
Abstract:
The invention provides supramolecular metal complexes as DNA cleaving agents. In the complexes, charge is transferred from one light absorbing metal (e.g. Ru or Os) to an electron accepting metal (e.g. Rh) via a bridging π-acceptor ligand. A bioactive metal-to-metal charge transfer state capable of cleaving DNA is thus generated. The complexes function when irradiated with low energy visible light with or without molecular oxygen.
Public/Granted literature
- US20100047910A1 SUPRAMOLECULAR COMPLEXES AS PHOTOACTIVATED DNA CLEAVAGE AGENTS Public/Granted day:2010-02-25
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