Invention Grant
- Patent Title: CETP inhibitors derived from benzoxazole arylamides
- Patent Title (中): 衍生自苯并恶唑芳酰胺的CETP抑制剂
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Application No.: US12664757Application Date: 2008-06-16
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Publication No.: US08445480B2Publication Date: 2013-05-21
- Inventor: Julianne A. Hunt , Ramzi F. Sweis , Dooseop Kim , Florida Kallashi , Peter J. Sinclair
- Applicant: Julianne A. Hunt , Ramzi F. Sweis , Dooseop Kim , Florida Kallashi , Peter J. Sinclair
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent James L. McGinnis; Catherine D. Fitch
- International Application: PCT/US2008/007467 WO 20080616
- International Announcement: WO2008/156715 WO 20081224
- Main IPC: A61K31/553
- IPC: A61K31/553 ; A61K31/5377 ; A61K31/506 ; A61K31/443 ; A61K31/4525 ; A61K31/423 ; A61K31/438 ; C07D239/42 ; C07D267/10 ; C07D413/14 ; C07D401/14 ; C07D221/20 ; C07D211/26 ; C07D263/57

Abstract:
Compounds having the structure of Formula I1 including pharmaceutically acceptable salts of the compounds, are potent CETP (cholesterol ester transfer protein) inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis Atherosclerosis and its clinical consequences, coronary heart disease (CHD), stroke and penpheral vascular disease, represent a truly enormous burden to the health care systems of the industrialized world In formula I, A-B is an arylamide moiety.
Public/Granted literature
- US20100298288A1 CETP INHIBITORS DERIVED FROM BENZOXAZOLE ARYLAMIDES Public/Granted day:2010-11-25
Information query
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