Invention Grant
- Patent Title: Scaffold-diversified pyrrolidinone derivatives and their use
- Patent Title (中): 支架多样化的吡咯烷酮衍生物及其用途
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Application No.: US12543792Application Date: 2009-08-19
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Publication No.: US08445481B2Publication Date: 2013-05-21
- Inventor: Sergey A. Kozmin , Jiayue Cui , Robert Haselkorn , Piotr Gornicki , Olesya Ulanovskaya , Stephen Kron
- Applicant: Sergey A. Kozmin , Jiayue Cui , Robert Haselkorn , Piotr Gornicki , Olesya Ulanovskaya , Stephen Kron
- Applicant Address: US IL Chicago
- Assignee: The University of Chicago
- Current Assignee: The University of Chicago
- Current Assignee Address: US IL Chicago
- Agency: Brinks Hofer Gilson & Lione
- Main IPC: A61K31/495
- IPC: A61K31/495 ; A61K31/437 ; C07D221/04 ; C07D209/04

Abstract:
The present disclosure provides novel compounds of the formula (I): wherein R0, R1, R2, R3, R4, R5, and R6 are as defined in the detailed description. Two preferred compounds of formulae (IX) and (X) are disclosed. Also disclosed are uses of the disclosed compounds, for example, in regulating glucose transport and in inhibiting acetyl coenzyme A carboxylase.
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