Invention Grant
US08445492B2 Method for inhibiting growth of cancer cells and cell telomere and diseases of cell proliferation by using heteroannelated anthraquinone derivative compounds
有权
通过使用异化的蒽醌衍生物化合物抑制癌细胞和细胞端粒的生长和细胞增殖的疾病的方法
- Patent Title: Method for inhibiting growth of cancer cells and cell telomere and diseases of cell proliferation by using heteroannelated anthraquinone derivative compounds
- Patent Title (中): 通过使用异化的蒽醌衍生物化合物抑制癌细胞和细胞端粒的生长和细胞增殖的疾病的方法
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Application No.: US12749185Application Date: 2010-03-29
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Publication No.: US08445492B2Publication Date: 2013-05-21
- Inventor: Hsu-Shan Huang
- Applicant: Hsu-Shan Huang
- Applicant Address: TW Taipei
- Assignee: National Defense Medical Center
- Current Assignee: National Defense Medical Center
- Current Assignee Address: TW Taipei
- Agency: Volpe and Koenig, P.C.
- Priority: TW97112087A 20080402
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A01N43/60 ; A01N43/52 ; A61K31/50 ; A61K31/495 ; A61K31/415 ; C07D265/30 ; C07D295/00

Abstract:
A heteroannelated anthraquinone derivative compound is provided. The heteroannelated anthraquinone derivative compound is represented by a formula (I): wherein R1 is a substituent being one selected from a group consisting of i) a first substituent being one selected from a group consisting of a hydryl group, an amino group, a nitro group, a hydroxyl group and a cyan group, ii) a second substituent being one selected from a group consisting of (CH2)nX, a straight (CH2)n alkyl group, a (CH2)n alkoxyl group, a branched (CH2)n alkyl group, a C3˜C12 naphthenic group, and a C3˜C12 cyclic alkoxyl group, wherein 1≦n≦12, and X is a halogen, iii) a third substituent being one selected from a group consisting of a straight C1˜C8 alkyl group with a double-bond, a C1˜C8 alkoxyl group with a double-bond, a branched C1˜C8 alkyl group with a double-bond and a C3˜C8 naphthenic group with a double-bond, and iv) a fourth substituent of a C5˜C12 heterocyclic group.
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