Invention Grant
US08445511B2 Quinoline or quinoxaline derivatives for treating neurodegenerative diseases
失效
用于治疗神经变性疾病的喹啉或喹喔啉衍生物
- Patent Title: Quinoline or quinoxaline derivatives for treating neurodegenerative diseases
- Patent Title (中): 用于治疗神经变性疾病的喹啉或喹喔啉衍生物
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Application No.: US13003992Application Date: 2009-07-20
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Publication No.: US08445511B2Publication Date: 2013-05-21
- Inventor: Fanny Schmidt , Bruno Figadere , Sylvia Rita Vozari , Pierre Champy , Xavier Franck
- Applicant: Fanny Schmidt , Bruno Figadere , Sylvia Rita Vozari , Pierre Champy , Xavier Franck
- Applicant Address: FR Paris
- Assignee: Centre National de la Recherche Scientifique (SNRS)
- Current Assignee: Centre National de la Recherche Scientifique (SNRS)
- Current Assignee Address: FR Paris
- Agency: Foley & Lardner LLP
- Priority: FR0854921 20080718
- International Application: PCT/EP2009/059285 WO 20090720
- International Announcement: WO2010/007179 WO 20100121
- Main IPC: A61K31/47
- IPC: A61K31/47

Abstract:
The present invention relates to compounds of Formula (I) below, to their pharmaceutically acceptable salts and to their isomers or mixtures of isomers: HetAr—X—CHR1R2 (I) in which: —HetAr represents a group chosen from: —X represents a linear, saturated or unsaturated, hydrocarbon-based chain comprising from 8 to 22 carbon atoms, optionally interrupted by an —NH— or —NH—CO— group, —R1 represents a hydrogen atom or an —OH, —O(C1-C6)alkyl, —OCO((C1-C6)alkyl), —OSO2((C1-C6)alkyl) or —OSO3H group, and —R2 represents a hydrogen atom or a (C2-C6)alkynyl, (C2-C6)alkenyl or (C3-C6)cycloalkyl group. The present invention also relates to a process for preparing the compounds of Formula (I), and also to the use thereof, especially in the treatment of neurodegenerative diseases.
Public/Granted literature
- US20110118270A1 HETEROCYCLIC DERIVATIVES THAT ARE USED IN THE TREATMENT OF NEURODEGENERATIVE DISEASES Public/Granted day:2011-05-19
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