Invention Grant
- Patent Title: Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals
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Application No.: US13632546Application Date: 2012-10-01
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Publication No.: US08445530B2Publication Date: 2013-05-21
- Inventor: Matthias Schaefer , Josef Pernerstorfer , Dieter Kadereit , Hartmut Strobel , Werngard Czechtizky , L. Charlie Chen , Alena Safarova , Aleksandra Weichsel , Marcel Patek
- Applicant: Sanofi
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agent Jiang Lin
- Priority: EP08290427 20080505
- Main IPC: A61K31/381
- IPC: A61K31/381 ; A61K31/435 ; C07D333/78 ; C07D221/04
Abstract:
The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Public/Granted literature
- US20130030008A1 ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2013-01-31
Information query
