Invention Grant
US08445638B2 Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells
失效
使用截短的eIF-5A1多核苷酸诱导癌细胞凋亡
- Patent Title: Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells
- Patent Title (中): 使用截短的eIF-5A1多核苷酸诱导癌细胞凋亡
-
Application No.: US12552746Application Date: 2009-09-02
-
Publication No.: US08445638B2Publication Date: 2013-05-21
- Inventor: John E. Thompson , Zhong Sun , Catherine A. Taylor , Richard Dondero , Zhenyu Cheng
- Applicant: John E. Thompson , Zhong Sun , Catherine A. Taylor , Richard Dondero , Zhenyu Cheng
- Applicant Address: US NJ Bridgewater
- Assignee: Senesco Technologies, Inc.
- Current Assignee: Senesco Technologies, Inc.
- Current Assignee Address: US NJ Bridgewater
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.The present invention also relates to a truncated form of eIF-5A1 that is useful for inducing apoptosis and killing of cells, especially cancer cells in a mammal.
Public/Granted literature
- US20100076062A1 Use of a Truncated eIF-5A1 Polynucleotide to Induce Apoptosis in Cancer Cells Public/Granted day:2010-03-25
Information query
IPC分类:
