Invention Grant
- Patent Title: Antibiotic macrocycle compounds and methods of manufacture and use thereof
- Patent Title (中): 抗生素大环化合物及其制备和使用方法
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Application No.: US13280148Application Date: 2011-10-24
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Publication No.: US08445654B2Publication Date: 2013-05-21
- Inventor: Yoshi Ichikawa , Yu-Hung Chiu , Youe-Kong Shue , Farah Kondori Babakhani
- Applicant: Yoshi Ichikawa , Yu-Hung Chiu , Youe-Kong Shue , Farah Kondori Babakhani
- Applicant Address: US NJ Jersey City
- Assignee: Optimer Pharmaceuticals, Inc.
- Current Assignee: Optimer Pharmaceuticals, Inc.
- Current Assignee Address: US NJ Jersey City
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: C07H17/08
- IPC: C07H17/08
Abstract:
The invention encompasses an active metabolite of the 18-membered macrocyclic antimicrobial agents, specifically, a metabolite of tiacumicin B and in certain embodiments, R-Tiacumicin B or and its related compounds. In particular, the invention encompasses a compound that acts as a potent antibiotic agent for the treatment of bacterial infections, specifically GI infections caused by toxin producing strains of Clostridium difficile (C. difficile) and Clostridium perfringens (C. perfringens).
Public/Granted literature
- US20120040922A1 ANTIBIOTIC MACROCYCLE COMPOUNDS AND METHODS OF MANUFACTURE AND USE THEREOF Public/Granted day:2012-02-16
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