Invention Grant
US08445687B2 Process for the preparation of a RAF kinase inhibitor and intermediates for use in the process
有权
用于制备RAF激酶抑制剂和用于该方法的中间体的方法
- Patent Title: Process for the preparation of a RAF kinase inhibitor and intermediates for use in the process
- Patent Title (中): 用于制备RAF激酶抑制剂和用于该方法的中间体的方法
-
Application No.: US12677195Application Date: 2008-09-10
-
Publication No.: US08445687B2Publication Date: 2013-05-21
- Inventor: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan , Maruti Ghagare , Sandip Chikhalikar
- Applicant: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan , Maruti Ghagare , Sandip Chikhalikar
- Applicant Address: IN Mumbai
- Assignee: Cipla Limited
- Current Assignee: Cipla Limited
- Current Assignee Address: IN Mumbai
- Agency: Conley Rose, P.C.
- Agent Rodney B. Carroll
- Priority: IN1733/MUM/2007 20070910; IN1734/MUM/2007 20070910
- International Application: PCT/GB2008/003048 WO 20080910
- International Announcement: WO2009/034308 WO 20090319
- Main IPC: C07D213/81
- IPC: C07D213/81 ; A61K31/44
Abstract:
There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A) wherein R′ is selected from the group consisting of hydrogen, —C(O)OA, —C(O)CX3, —C(O)NH2, —C(O)—NHOH or There is also provided intermediate compounds of general formula (A), N-methyl-4-(4-ureidophenoxy)picolinamide, 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2-trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib.
Public/Granted literature
- US20100311980A1 Process for the Preparation of a RAF Kinase Inhibitor and Intermediates for Use in the Process Public/Granted day:2010-12-09
Information query
IPC分类:
