Invention Grant
US08445688B2 Process for producing enantiomer of amlodipine in high optical purity
有权
以高光学纯度制备氨氯地平的对映异构体的方法
- Patent Title: Process for producing enantiomer of amlodipine in high optical purity
- Patent Title (中): 以高光学纯度制备氨氯地平的对映异构体的方法
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Application No.: US12895303Application Date: 2010-09-30
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Publication No.: US08445688B2Publication Date: 2013-05-21
- Inventor: Milind Moreshwar Gharpure , Baburao Manikrao Bhawal , Prasad Vasudeo Ranade , Rajendra Dagadu Deshmukh , Satish Ramanlal Mehta
- Applicant: Milind Moreshwar Gharpure , Baburao Manikrao Bhawal , Prasad Vasudeo Ranade , Rajendra Dagadu Deshmukh , Satish Ramanlal Mehta
- Applicant Address: IN Maharashtra
- Assignee: Emcure Pharmaceuticals Limited
- Current Assignee: Emcure Pharmaceuticals Limited
- Current Assignee Address: IN Maharashtra
- Agency: Foley & Lardner LLP
- Priority: IN1123/MUM/2004 20041020
- Main IPC: C07D211/86
- IPC: C07D211/86
Abstract:
The present invention relates to a process for preparation of optically pure (S)-amlodipine-L-hemitartrate DMF solvate comprising the steps of treating (R,S) amlodipine base with L-tartaric acid in the presence of dimethyl formamide and a co-solvent. The invention also relates to a process for converting (R) or (S)-amlopidine-L-hemitartrate DMF solvate into their besylates without isolating free chiral amlopidine base after solution.
Public/Granted literature
- US20110021783A1 PROCESS FOR PRODUCING ENANTIOMER OF AMLODIPINE IN HIGH OPTICAL PURITY Public/Granted day:2011-01-27
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