Invention Grant
- Patent Title: Hydrazonopyrazole derivatives and their use as therapeutics
- Patent Title (中): 肼吡唑衍生物及其作为治疗剂的用途
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Application No.: US12977794Application Date: 2010-12-23
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Publication No.: US08445694B2Publication Date: 2013-05-21
- Inventor: Zaihui Zhang , Timothy S. Daynard , Mikhail A. Chafeev , Shisen Wang , Gregory B. Chopiuk , Serguei V. Sviridov
- Applicant: Zaihui Zhang , Timothy S. Daynard , Mikhail A. Chafeev , Shisen Wang , Gregory B. Chopiuk , Serguei V. Sviridov
- Applicant Address: US CA Redwood City
- Assignee: Dermira (Canada), Inc.
- Current Assignee: Dermira (Canada), Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Seed IP Law Group PLLC
- Main IPC: C07D231/38
- IPC: C07D231/38 ; A61K31/415
Abstract:
Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
Public/Granted literature
- US20110237783A1 HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS Public/Granted day:2011-09-29
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