Invention Grant
- Patent Title: Method of synthesizing fenofibrate
- Patent Title (中): 非诺贝特合成方法
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Application No.: US12600515Application Date: 2008-07-02
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Publication No.: US08445715B2Publication Date: 2013-05-21
- Inventor: Beatrice Lucas
- Applicant: Beatrice Lucas
- Applicant Address: FR Chenove
- Assignee: Synkem
- Current Assignee: Synkem
- Current Assignee Address: FR Chenove
- Agency: Ladas & Parry LLP
- Priority: FR0756220 20070702
- International Application: PCT/EP2008/058511 WO 20080702
- International Announcement: WO2009/004029 WO 20090108
- Main IPC: C07C69/76
- IPC: C07C69/76 ; C07C69/95

Abstract:
A novel process for the synthesis of fenofibrate, includes reacting a metal salt of fenofibric acid with an isopropyl halide, in a solvent system composed of a mixture of dimethyl sulfoxide and a C2-C4 alkyl acetate. The process can be used on an industrial scale and makes it possible to obtain a fenofibrate of a quality in accordance with the Pharmacopoeia without the need for purification by recrystallization.
Public/Granted literature
- US20120065421A1 NOVEL METHOD OF SYNTHESIZING FENOFIBRATE Public/Granted day:2012-03-15
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