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US08445715B2 Method of synthesizing fenofibrate 有权
非诺贝特合成方法

  • Patent Title: Method of synthesizing fenofibrate
  • Patent Title (中): 非诺贝特合成方法
  • Application No.: US12600515
    Application Date: 2008-07-02
  • Publication No.: US08445715B2
    Publication Date: 2013-05-21
  • Inventor: Beatrice Lucas
  • Applicant: Beatrice Lucas
  • Applicant Address: FR Chenove
  • Assignee: Synkem
  • Current Assignee: Synkem
  • Current Assignee Address: FR Chenove
  • Agency: Ladas & Parry LLP
  • Priority: FR0756220 20070702
  • International Application: PCT/EP2008/058511 WO 20080702
  • International Announcement: WO2009/004029 WO 20090108
  • Main IPC: C07C69/76
  • IPC: C07C69/76 C07C69/95
Method of synthesizing fenofibrate
Abstract:
A novel process for the synthesis of fenofibrate, includes reacting a metal salt of fenofibric acid with an isopropyl halide, in a solvent system composed of a mixture of dimethyl sulfoxide and a C2-C4 alkyl acetate. The process can be used on an industrial scale and makes it possible to obtain a fenofibrate of a quality in accordance with the Pharmacopoeia without the need for purification by recrystallization.
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