The present disclosure is directed to a system and method for multiplexing radio frequency signals. In some implementations, a system includes a host coupling module, a plurality of antennas, and a processing module. The host coupling module is configured to receive and transmit RF signals through a wired connection. The plurality of antennas are configured to wirelessly transmit RF signals and receive RF signals from RFID tags. The processing module is configured to selectively switch between the plurality of antennas for communication with the RFID tags using the host coupling module and backscatter at least a portion of the received RF signals through the wired connection to communicate information independent of an internal power supply.