An Apparatus and a method for interference cancellation in a wireless communication system are provided. When a resource of an Interference Cancellation (IC) zone is allocated to a terminal traveling in a service coverage, resource allocation information relating to an IC zone of neighbor cells is gathered. Resource allocation information is generated relating to the resource allocated to the terminal comprising resource allocation information of the IC zone of the neighbor cells. The resource allocation information relating to the resource allocated to the terminal is transmitted to the terminal. Accordingly, when the interference is present, the interference cancellation is carried out to reduce the load on the terminal and enhance the reception performance.