An electronic device with a cleaning mechanism that is capable of cleaning a display panel thereof is provided. The electronic device includes a display panel, a main portion, a hinge structure, a sliding device, and a first spring. The hinge structure includes a fixing portion, a rotating portion having a first contact surface, and a spring holder having a second contact surface. When the rotating portion rotates on the fixing portion, the first contact surface contacts the second contact surface and presses against the spring holder so that it rotates with the rotating portion. The sliding device includes a cleaning material contacting the display panel. Two end portions of the first spring are respectively fixed to the spring holder and the sliding device. When the spring holder stretches the first spring to move the sliding device, the cleaning material cleans the display panel.