Enhanced granularity operational parameters adjustment of components and modules in a multi-band, multi-standard communication device. For supporting two-way communications, a communication device includes receiver and transmitter modules. Each module includes various components that are configurable and/or programmable based on a protocol and band pair by which the communication device is operating. The communication device is a multi-protocol and multi-band capable communication device capable to operate in accordance with any one protocol and band at a first time and another protocol and band at a second time. The various components within each of the receiver and transmitter modules can be adjusted using one or more operational parameters. In some instances, a given component can be controlled by more than one operational parameter. Alternatively, certain components are controlled only one operational parameter. The operational parameters that configure the components may be calculated, retrieved from a memory, and/or determined using other means.