A packaging system for cold chain shipment may include a container having interior surface portions, a plurality of cellulose sheets disposed along the interior surface portions and defining a space configured to receive an item for cold chain shipment, and a cold source disposed within the space and configured to cool the container for cold chain shipment. The packaging system may further include a plurality of cellulose sheets, wherein adjacent sheets of the plurality of cellulose sheets define a plurality of pockets configured to trap air, and wherein the plurality of cellulose sheets are configured to insulate the space.