A method of marking and optionally treating a tissue sample, the method having the steps of: (a) providing an instrument including a needle having an opening and a clip delivery device within the needle, wherein the clip delivery device includes an opening coexisting with the opening of the needle; and (b) delivering a clip to a biopsy site, wherein the clip includes an encasement adapted to provide treatment to tissue sample; wherein delivery of the clip is essentially free of a step of longitudinal re-positioning of greater than about 3 mm by the user of the needle or clip delivery device so that the clip is precisely deployed to a central portion of the biopsy site.