Invention Grant
US08454987B2 Biocompatible transparent sheet, method for producing the same, and cultured cell sheet used the same sheet
有权
生物相容性透明片,其制造方法和使用同一片的培养细胞片
- Patent Title: Biocompatible transparent sheet, method for producing the same, and cultured cell sheet used the same sheet
- Patent Title (中): 生物相容性透明片,其制造方法和使用同一片的培养细胞片
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Application No.: US12225256Application Date: 2007-03-14
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Publication No.: US08454987B2Publication Date: 2013-06-04
- Inventor: Shigeki Hontsu , Hiroaki Nishikawa , Masanobu Kusunoki , Ryouta Hatanaka
- Applicant: Shigeki Hontsu , Hiroaki Nishikawa , Masanobu Kusunoki , Ryouta Hatanaka
- Applicant Address: JP Osaka JP Saitama
- Assignee: Kinki University,Japan Science and Technology
- Current Assignee: Kinki University,Japan Science and Technology
- Current Assignee Address: JP Osaka JP Saitama
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2006-074254 20060317
- International Application: PCT/JP2007/055028 WO 20070314
- International Announcement: WO2007/108373 WO 20070927
- Main IPC: A61K9/00
- IPC: A61K9/00 ; B32B18/00 ; B32B3/24 ; A61P43/00 ; A61K35/12

Abstract:
The present invention provides a flexible, biocompatible transparent sheet (8) which has high biocompatibility and a high ability to adsorb a biologically relevant substance, which can be used as a novel biomaterial, and which can be used to observe the propagation, differentiation, and/or the like of living cells in real time. The biocompatible transparent sheet (8) is produced in such a manner that a biocompatible ceramic film (2) is formed on a substrate (1) soluble in a solvent (11) incapable of dissolving biocompatible ceramics by using exemplary a laser ablation process, the substrate (1) depositing the film (2) is dipped in the solvent (11) and dissolved off, and the isolated film (2) is then dried. The biocompatible transparent sheet (8) is utilizable of producing a flexible cultured cell sheet which can be directly transplanted to an affected area. The cell sheet can be prepared in such a manner that cells are seeded on the biocompatible transparent sheet (8) and then propagated.
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