Invention Grant
- Patent Title: Method to facilitate directed delivery and electroporation using a charged stream
- Patent Title (中): 使用带电流促进定向递送和电穿孔的方法
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Application No.: US12207846Application Date: 2008-09-10
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Publication No.: US08455228B2Publication Date: 2013-06-04
- Inventor: Mark Jaroszeski , Gabriel A. Lopez-Diaz , Richard J. Connolly , Andrew M. Hoff
- Applicant: Mark Jaroszeski , Gabriel A. Lopez-Diaz , Richard J. Connolly , Andrew M. Hoff
- Applicant Address: US FL Tampa
- Assignee: University of South Florida
- Current Assignee: University of South Florida
- Current Assignee Address: US FL Tampa
- Agency: Smith & Hopen, P.A.
- Agent Michele L. Lawson
- Main IPC: C12N13/00
- IPC: C12N13/00
Abstract:
A method for facilitating a delivery of a molecule into an interior space of a cell includes the steps of introducing a molecule into a biological structure comprising a cell and applying a substantially continuous low-level electric field, in the form of non-thermal plasma (ionized gas) generated by a direct current voltage applied to an electrode, to the molecule and biological structure. The field is applied for a duration sufficient to effect a change in porosity the cell of the biological structure sufficient to facilitate an entry of a desired molecule into an interior thereof.
Public/Granted literature
- US20090004717A1 Device and Method to Facilitate Directed Delivery and Electroporation Using a Charged Stream Public/Granted day:2009-01-01
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