Invention Grant
- Patent Title: Protease variants for pharmaceutical use
- Patent Title (中): 用于药物用途的蛋白酶变体
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Application No.: US12745652Application Date: 2008-12-02
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Publication No.: US08455235B2Publication Date: 2013-06-04
- Inventor: Allan Svendsen , Lars Beier , Signe Eskildsen Larsen , Thomas Lenhard , Tanja Maria Rosenkilde Kjaer , Peter Colin Gregory
- Applicant: Allan Svendsen , Lars Beier , Signe Eskildsen Larsen , Thomas Lenhard , Tanja Maria Rosenkilde Kjaer , Peter Colin Gregory
- Applicant Address: DK Bagsvaerd DE Hannover
- Assignee: Novozymes A/S,Solvay Pharmaceuticals, GmbH
- Current Assignee: Novozymes A/S,Solvay Pharmaceuticals, GmbH
- Current Assignee Address: DK Bagsvaerd DE Hannover
- Agent Elias Lambiris
- Priority: EP07122243 20071204
- International Application: PCT/EP2008/066646 WO 20081202
- International Announcement: WO2009/071550 WO 20090611
- Main IPC: C12N9/52
- IPC: C12N9/52 ; A61K38/48 ; A23K1/165
Abstract:
The invention relates to novel variants of a protease derived from Nocardiopsis sp. (SEQ ID NO: 1) and closely related proteases, as well as their pharmaceutical use. The variants show improved performance in the treatment of pancreatic exocrine insufficiency (PEI). The variants may be combined with a lipase and/or an amylase. Other examples of medical indications are: Treatment of digestive disorders, pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.
Public/Granted literature
- US20100322915A1 Protease Variants for Pharmaceutical Use Public/Granted day:2010-12-23
Information query
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