Invention Grant
US08455237B2 Escherichia coli strain with phosphoenolpyruvate carboxylase promoter replaced with cysteine synthase promoter and method of enhanced production of L-threonine using the same
有权
具有用半胱氨酸合成酶启动子取代的具有磷酸烯醇丙酮酸羧化酶启动子的大肠杆菌菌株和使用其同时增强L-苏氨酸生产的方法
- Patent Title: Escherichia coli strain with phosphoenolpyruvate carboxylase promoter replaced with cysteine synthase promoter and method of enhanced production of L-threonine using the same
- Patent Title (中): 具有用半胱氨酸合成酶启动子取代的具有磷酸烯醇丙酮酸羧化酶启动子的大肠杆菌菌株和使用其同时增强L-苏氨酸生产的方法
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Application No.: US12812203Application Date: 2009-01-07
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Publication No.: US08455237B2Publication Date: 2013-06-04
- Inventor: Kwang Ho Lee , Jae Yeong Ju , Ji Sun Lee , Young Bin Hwang , Sung Hoo Jhon , Eun Sung Koh , Chul Ha Kim , Soo An Shin
- Applicant: Kwang Ho Lee , Jae Yeong Ju , Ji Sun Lee , Young Bin Hwang , Sung Hoo Jhon , Eun Sung Koh , Chul Ha Kim , Soo An Shin
- Applicant Address: KR
- Assignee: CJ Cheiljedang Corp.
- Current Assignee: CJ Cheiljedang Corp.
- Current Assignee Address: KR
- Agency: Cantor Colburn LLP
- Priority: KR10-2008-0002310 20080108
- International Application: PCT/KR2009/000066 WO 20090107
- International Announcement: WO2009/088216 WO 20090716
- Main IPC: C12N1/20
- IPC: C12N1/20
Abstract:
An L-threonine-producing Escherichia coli in which a promoter of a phosphoenolpyruvate carboxylase (ppc) gene on the chromosome is substituted with a promoter of a cysteine synthase (cysK) gene and a method of producing L-threonine by using the same are disclosed. The recombinant Escherichia coli may produce L-threonine in a high yield, and thus may be widely used in medical, pharmaceutical, and feed industries, particularly for an animal feed.
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