Invention Grant
- Patent Title: Highly effective anti-cadherin antibody for induction of antibody-dependent cellular cytotoxicity in vivo
- Patent Title (中): 用于诱导体内抗体依赖性细胞毒性的高效抗钙粘蛋白抗体
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Application No.: US13318422Application Date: 2010-04-30
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Publication No.: US08455249B2Publication Date: 2013-06-04
- Inventor: Hiroyuki Aburatani , Lilin Zhang , Keisuke Ishii , Katsushi Kouda , Aya Sakamoto , Keiko Katsumi , Hiroshi Onishi , Yoko Kayukawa
- Applicant: Hiroyuki Aburatani , Lilin Zhang , Keisuke Ishii , Katsushi Kouda , Aya Sakamoto , Keiko Katsumi , Hiroshi Onishi , Yoko Kayukawa
- Applicant Address: JP Tokyo JP Tokyo
- Assignee: The University of Tokyo,Perseus Proteomics Inc.
- Current Assignee: The University of Tokyo,Perseus Proteomics Inc.
- Current Assignee Address: JP Tokyo JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2009-111834 20090501; JP2010-018416 20100129
- International Application: PCT/JP2010/057694 WO 20100430
- International Announcement: WO2010/126137 WO 20100411
- Main IPC: C12N5/07
- IPC: C12N5/07 ; C07K16/00
Abstract:
It is an object of the present invention to provide an anti-cadherin antibody having high antibody-dependent cellular cytotoxicity. The present invention provides an anti-cadherin antibody, which recognizes any one of an upstream region of EC1, a cadherin domain 4 (EC4) and a cadherin domain 5 (EC5), wherein an antibody-dependent cellular cytotoxicity at an antibody concentration of 1 μg/mL is 30% or more.
Public/Granted literature
- US20120136140A1 ANTI-CADHERIN ANTIBODY Public/Granted day:2012-05-31
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