Invention Grant
- Patent Title: Inhibitors of the trypsin-like site of the proteasome and methods of use thereof
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Application No.: US13399189Application Date: 2012-02-17
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Publication No.: US08455431B2Publication Date: 2013-06-04
- Inventor: Alexei Kisselev , Dmitry V. Filippov , Herman Overkleeft
- Applicant: Alexei Kisselev , Dmitry V. Filippov , Herman Overkleeft
- Applicant Address: US NH Hanover NL Leiden
- Assignee: Trustees of Dartmout College,Leiden University
- Current Assignee: Trustees of Dartmout College,Leiden University
- Current Assignee Address: US NH Hanover NL Leiden
- Agency: Licata & Tyrell P.C.
- Main IPC: A61P33/00
- IPC: A61P33/00
Abstract:
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the β2/β2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
Public/Granted literature
- US20120214732A1 Inhibitors of the Trypsin-Like Site of the Proteasome and Methods of Use Thereof Public/Granted day:2012-08-23
Information query
IPC分类:
| A | 人类生活必需 |
| A61 | 医学或兽医学；卫生学 |
| A61P | 化合物或药物制剂的特定治疗活性 |
| A61P33/00 | 抗寄生虫药 |
