Invention Grant
- Patent Title: Process for solubilizing glucagon-like peptide 1 compounds
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Application No.: US13571443Application Date: 2012-08-10
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Publication No.: US08455433B2Publication Date: 2013-06-04
- Inventor: Walter Francis Prouty, Jr. , Joseph Vincent Rinella, Jr.
- Applicant: Walter Francis Prouty, Jr. , Joseph Vincent Rinella, Jr.
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Andrea M. Castetter
- Main IPC: A61K38/26
- IPC: A61K38/26 ; A61K38/00
Abstract:
Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.
Public/Granted literature
- US20130072658A1 PROCESS FOR SOLUBILIZING GLUCAGON-LIKE PEPTIDE 1 COMPOUNDS Public/Granted day:2013-03-21
Information query
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