Invention Grant
- Patent Title: Antidotes for factor Xa inhibitors and methods of using the same in combination with blood coagulating agents
- Patent Title (中): 因子Xa抑制剂的解毒剂及其与血液凝结剂组合使用的方法
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Application No.: US12616735Application Date: 2009-11-11
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Publication No.: US08455439B2Publication Date: 2013-06-04
- Inventor: Genmin Lu , Uma Sinha
- Applicant: Genmin Lu , Uma Sinha
- Applicant Address: US CA South San Francisco
- Assignee: Portola Pharmaceuticals, Inc.
- Current Assignee: Portola Pharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Foley & Lardner LLP
- Main IPC: A61K38/57
- IPC: A61K38/57 ; A61K35/14 ; C07K14/745 ; C07K14/81
Abstract:
The present invention relates to antidotes of anticoagulants targeting factor Xa which antidotes are used in combination with blood coagulating agents or other heparin antidotes to prevent or reduce bleeding in a subject. The antidotes described herein have reduced or no intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is or will be undergoing anticoagulant therapy with a factor Xa inhibitor.
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