Invention Grant
- Patent Title: Compositions and methods for silencing genes involved in hemorrhagic fever
- Patent Title (中): 沉默参与出血热的基因的组成和方法
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Application No.: US13077856Application Date: 2011-03-31
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Publication No.: US08455455B1Publication Date: 2013-06-04
- Inventor: Marjorie Robbins , Susan de Jong , Vandana Sood , Lisa E. Hensley , Ian MacLachlan
- Applicant: Marjorie Robbins , Susan de Jong , Vandana Sood , Lisa E. Hensley , Ian MacLachlan
- Applicant Address: CA Burnaby, BC US DC Washington
- Assignee: Protiva Biotherapeutics, Inc.,The United States Army Medical Research and Materiel Command
- Current Assignee: Protiva Biotherapeutics, Inc.,The United States Army Medical Research and Materiel Command
- Current Assignee Address: CA Burnaby, BC US DC Washington
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K31/70 ; C12Q1/68 ; C12N5/00
Abstract:
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target Lassa virus (LASV) or tissue factor (TF) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for treating hemorraghic fever).
Information query
