Invention Grant
US08455456B2 Compositions and their uses directed to diacylglycerol acyltransferase 1
失效
组合物及其用于二酰基甘油酰基转移酶的用途1
- Patent Title: Compositions and their uses directed to diacylglycerol acyltransferase 1
- Patent Title (中): 组合物及其用于二酰基甘油酰基转移酶的用途1
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Application No.: US13177457Application Date: 2011-07-06
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Publication No.: US08455456B2Publication Date: 2013-06-04
- Inventor: Xing-Xian Yu , Sanjay Bhanot , Brett P. Monia
- Applicant: Xing-Xian Yu , Sanjay Bhanot , Brett P. Monia
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; C12Q1/68 ; C12N5/00
Abstract:
Disclosed herein are compounds, compositions and methods for modulating DGAT-1 activity. Preferably, the expression of DGAT-1 from a nucleic acid is inhibited. Methods are provided for treating, ameliorating or treating liver fibrosis, either directly or by treating an underlying etiological factor. Preferably, the treatment, amelioration or prevention comprises administering a DGAT-1 activity modulator.
Public/Granted literature
- US20120029050A1 COMPOSITIONS AND THEIR USES DIRECTED TO DIACYLGLYCEROL ACYLTRANSFERASE 1 Public/Granted day:2012-02-02
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